Endocrine Abstracts

Nowadays fat tissue is considered as endocrine organ responsible for metabolism of sex hormones. Obesity is accompanied by a decrease in biosynthesis of 17β-estradiol (2-hydroxyestrone) inactive metabolites and increased production of aggressive metabolites (16-hydroxyestrone). This factor leads to hyperproliferative syndrome, which includes hormonal-dependent lesions of target organs: uterine leiomyomas, adenomyosis, hyperplasia of endometrium, tumor-like lesions of the ...

According to recent views, underlying cause and characteristic of type 2 diabetes mellitus (DM2), complicated by non-alcoholic fatty liver disease (NAFLD) is chronic systemic low-gradient inflammation, in which the leading role in liver damage and DM2 decompensation is given to the cytokine production. The purpose of this study was to compare the levels of interleukin 17 (IL-17) expression in patients with DM2 and NAFLD, as well as to assess the relationship between IL-17 and ...

Background: Leading position among endocrine pathology of adolescence and young women is type 1 diabetes (T1D), which in recent years had been proved to have a strong association with reproductive dysfunction among such patients. The purpose was to investigate the features of reproductive health in 120 young women (18–22 years old) with T1D.Methods: Retrospectively we studied the features of puberty and prospectively examined level of blood glucose ...

Background: Aromatase inhibitors have been introduced as a new treatment modality in controlled ovarian stimulation as they were found to elevate follicular sensitivity to gonadotropins.The purpose of this study was to evaluate whether IVF outcomes will differ between poor responder patients who receive high doses of gonadotropins alone or low doses of gonadotropins with letrozole during ovulation stimulation.Methods: Patients who ...

Background: Obesity is an excess accumulation of adipose tissue in the body, characterized by impaired lipid and carbohydrate metabolism with subsequent pathological changes. The purpose of this study was to investigate the functioning of the reproductive system, metabolic and immunological status in women of reproductive age with obesity and overweight.Methods: We examined 110 women of reproductive age including 60 patients with obesity (group I), 25 ov...

Association of type 2 diabetes, NAFLD, intestinal dysbiosis and endotoxemia is a trigger factor of cytokine cascade which manifest in proinflammatory state development, insulin resistance, hyperglycemia and dyslipidemia progression. The aim of this study is to reveal the effect of multiprobiotic Symbiter (symbiotic association of 14–24 strains of Bifidobacterium Lactobacillus, Propionibacterium, Lactococcus lactis, Streptococcus, Acetobacter aceti) and hepatoprotector Glu...

Background: One of the most significant complications of type 2 diabetes (T2D) is non-alcoholic fatty liver disease (NAFLD). The search for new effective approaches to the treatment of patients with comorbid chronic condition such as type 2 diabetes and NAFLD is relevant.Methods: We have observed 118 patients, including 64 patients with T2D and NAFLD, 26 patients with T2D and 28 patients with NAFLD. The control group consisted of 25 healthy indivi...